Description
An inhibitor of γ-secretase (IC50 = 15 nM for AAP cleavage to Aβ40); 14-fold selective for γ-secretase over Notch-1; reduces brain levels of Aβ40 and Aβ42 in the Tg2576 transgenic mouse model of Alzheimer's disease; also increases contextual fear conditioning freezing time in Tg2576 mice